Omantribune
Oman Tribune
Omantribune
Omantribune Search News
Web Oman
    Google Search Button
      Tribune
- Oman
- Soccer World Cup
- Other Top Stories
- Middle East
- Business
- Sports
- India
- Pakistan
- Asia
- Europe
- Americas
- Columnists
- Editorial
- Oman Mirror
- Special Features
- Cinema
- PDF Pages
- Weather
- Travel
- Currency Rate
- Hospitals
- Pharmacies
- Services
- Flight Timings
- Museum Timings
Omantribune Home Omantribune About Us Omantribune Advertising Information Omantribune Archives Omantribune Subscribe-Form Omantribune Jobs Omantribune Contact Us
Monday, December 22, 2014  
‘Good’ cholesterol to the rescue
Could cholesterol treatment fight repeat heart attacks? Randy Dotinga tries to find out

A biopharmaceutical company is developing a treatment that aims to prevent repeat heart attacks by using a component of ‘good’ cholesterol to clear arteries of dangerous cholesterol buildup.

“We hope what we have is a new mechanism to go after cholesterol in the days or weeks after a heart attack,” said Sam Wright, global strategic director of cardiovascular therapeutics at CSL Limited, which is headquartered in Australia.

The research is in the early stages, and it’s far from clear if the potential treatment will work. Still, the preliminary findings are positive, said Wright. And they were to be presented Monday at the annual meeting of the American Heart Association in Los Angeles.

According to Wright, up to 20 per cent of people who survive a heart attack have another one over the next year. The risk is highest in the first several weeks.

While heart surgeons can often prop open clogged arteries after a heart attack, other arteries can remain blocked, he said. “We’d like to remove the cholesterol from all the arteries and prevent blockades,” he said.

In the new study — which represents the first of three stages of research that drugs must undergo before winning approval in the United States — researchers gave intravenous doses of a protein from so-called “good” (HDL) cholesterol to 57 healthy volunteers.

The study found that the body quickly began to do a better job of removing ‘bad’ (LDL) cholesterol from cells. While scientists often say that every drug has side effects, the researchers saw no signs of adverse effects related to the treatment. The treatment appeared to work by boosting the body’s ability to dispose of “bad” cholesterol, Wright said. While aspirin and anti-platelet drugs prevent clotting after a heart attack, they don’t attack the cholesterol that has built up in artery plaque, the study authors noted.

The researchers are continuing to study the drug in people, and it’s unknown if it will actually help reduce the risk of heart attack. Also, it’s too early to estimate the cost or determine if it might prevent heart attacks in people with high cholesterol who haven’t had a heart attack, Wright said.

David Brown, a cardiologist and professor of medicine at Stony Brook University Medical Center in New York, predicted that the drug will be expensive. “It also involves processing of human blood, which comes with some risk of spreading infection,” he said. “Also, other drugs that increase HDL have not been shown to be of major clinical benefit.”

Brown also said it would be unlikely that the drug could be given to anyone with high cholesterol, even those who haven’t had heart attacks.

Gregg Fonarow, a professor of cardiology at University of California, Los Angeles, noted that the treatment is given intravenously, which “could be considered a significant drawback” compared to drugs taken by mouth.

It’s unclear how often patients would have to undergo the treatment.

Data and conclusions presented at meetings are typically considered preliminary until published in a peer-reviewed medical journal.

IHT-NYT News Syndicate
NEWS UPDATES
Oman
Foundation stone laid for Omani-owned Palm Mall
Ministry honours students, teachers and institutions
Middle East College staff explore Spain
‘Oman 2014-15’ published
Conservation of ecosystem on mountains stressed at forum
Dhofar governor visits PDO southern projects
Other Top Stories
Tunisia election marks transition to full democracy
Oman’s heritage inspires Zubair calendar
Liberia turnout low as Ebola fear keeps voters at home
US jets strike Baghdadi militia targets in Aleppo
MSM records highest 1-day gain in 5 years
India
Government, BJP seek consensus in conversion law
Conversion row won’t hit Modi’s development agenda, says Shah
3 workers killed in Manipur bomb blast
Shanghai seeks cooperation with Mumbai in IT, tourism sectors
Modi a man on a mission: Gabbard
Rape case reopened after 24 years
CBI to file final report in defence land scam
Congress leaders lock horns over liquor policy
Uranium production falls as Jharkhand mine stops operations
Napoleon quits DMK, joins BJP
Pakistan
Sympathisers of terrorists live among us: Nisar
Traumatised kids struggle to sleep
Lal Masjid cleric bows to pressure, condemns Peshawar massacre
Al Qaeda slams Taliban attack
Four Musharraf attackers hanged
Karachi hit by massive power breakdown
Christian group seeks own ‘census’
Middle East
Iraqi Kurds oust Baghdadi militia from north Sinjar
200 Gazans enter Egypt as Rafah reopens for two days
Sisi replaces spy chief
US-Cuba thaw shows curbs don’t work: Iran
US delivers Egypt 10 Apaches to counter terror in Sinai
Hassi asks envoys to come back
Jordan hangs 11 as death penalty ban revoked
Sudan forces raid rights group office
Asia
North Korea faces UN scrutiny over rights violations
Abbott shuffles cabinet, sets focus on financial issues, jobs
Taliban attack, roadside bomb claim 14 lives in Afghanistan
Seven killed in Philippines ‘hostage drama’ inferno
Australian mom charged with murder of eight kids
Smurfs, dwarves evoke Xmas spirit in China
Business
SGRF share purchase, attractive valuation make market buoyant
Global M&A deals rise 40%, hit 7-year high
S. Arabia, Kuwait not to cut oil output
Royalty settlement dents Ooredoo profit
Sebi widens black money probe
Iata seeks policy support to boost Indian carriers
Rajan seeks RBI autonomy amid rate cut rants
India cuts exposure to US securities to $77.5b
Xiaomi valuation to cross $45b after $1b fund-raising
Bumpy ride ahead for Russian economy
Europe
British N-power plants ‘highly vulnerable to drone attacks’
Belarus leader seeks to revive Ukraine talks
French cops kill man after police station attack
Turkish TV show fined over ‘dance with stranger’ stunt
Greek leftist lead shrinks in polls
Turkey accuses EU of starting ‘dirty campaign’
Italian couple saves horses from butcher’s knife
Sports
UAE win inaugural women’s Gulf Cup
Real are Club World Cup champs
Valencia move to fourth in La Liga
Qatar 2022 World Cup dates in March, says Fifa
Bremen upset Dortmund in Bundesliga
ISL champions Kolkata pocket Rs80m
Mavs end 10-game season losing streak
Azaan competes with top golfers
Accept DRS, players to BCCI
Ali in hospital with pneumonia
Aussie media slate ‘whingeing’ India after Test loss
Johnson secures Sunderland late win
Americas
Gunman kills two NY cops
Hundreds rally in US against police atrocities
Sony cyberattack not an act of war: Obama
US curbs aimed to ‘fuel unrest, oust Maduro’
Castro rejects change to political system after thaw in US ties

Sports


International

© 2013 Oman Tribune. All rights reserved. Best viewed in 800 X 600 resolution