Omantribune
Oman Tribune
Omantribune
Omantribune Search News
Web Oman
    Google Search Button
      Tribune
- Oman
- Soccer World Cup
- Other Top Stories
- Middle East
- Business
- Sports
- India
- Pakistan
- Asia
- Europe
- Americas
- Columnists
- Editorial
- Oman Mirror
- Special Features
- Cinema
- PDF Pages
- Weather
- Travel
- Currency Rate
- Hospitals
- Pharmacies
- Services
- Flight Timings
- Museum Timings
Omantribune Home Omantribune About Us Omantribune Advertising Information Omantribune Archives Omantribune Subscribe-Form Omantribune Jobs Omantribune Contact Us
Tuesday, September 30, 2014  
‘Good’ cholesterol to the rescue
Could cholesterol treatment fight repeat heart attacks? Randy Dotinga tries to find out

A biopharmaceutical company is developing a treatment that aims to prevent repeat heart attacks by using a component of ‘good’ cholesterol to clear arteries of dangerous cholesterol buildup.

“We hope what we have is a new mechanism to go after cholesterol in the days or weeks after a heart attack,” said Sam Wright, global strategic director of cardiovascular therapeutics at CSL Limited, which is headquartered in Australia.

The research is in the early stages, and it’s far from clear if the potential treatment will work. Still, the preliminary findings are positive, said Wright. And they were to be presented Monday at the annual meeting of the American Heart Association in Los Angeles.

According to Wright, up to 20 per cent of people who survive a heart attack have another one over the next year. The risk is highest in the first several weeks.

While heart surgeons can often prop open clogged arteries after a heart attack, other arteries can remain blocked, he said. “We’d like to remove the cholesterol from all the arteries and prevent blockades,” he said.

In the new study — which represents the first of three stages of research that drugs must undergo before winning approval in the United States — researchers gave intravenous doses of a protein from so-called “good” (HDL) cholesterol to 57 healthy volunteers.

The study found that the body quickly began to do a better job of removing ‘bad’ (LDL) cholesterol from cells. While scientists often say that every drug has side effects, the researchers saw no signs of adverse effects related to the treatment. The treatment appeared to work by boosting the body’s ability to dispose of “bad” cholesterol, Wright said. While aspirin and anti-platelet drugs prevent clotting after a heart attack, they don’t attack the cholesterol that has built up in artery plaque, the study authors noted.

The researchers are continuing to study the drug in people, and it’s unknown if it will actually help reduce the risk of heart attack. Also, it’s too early to estimate the cost or determine if it might prevent heart attacks in people with high cholesterol who haven’t had a heart attack, Wright said.

David Brown, a cardiologist and professor of medicine at Stony Brook University Medical Center in New York, predicted that the drug will be expensive. “It also involves processing of human blood, which comes with some risk of spreading infection,” he said. “Also, other drugs that increase HDL have not been shown to be of major clinical benefit.”

Brown also said it would be unlikely that the drug could be given to anyone with high cholesterol, even those who haven’t had heart attacks.

Gregg Fonarow, a professor of cardiology at University of California, Los Angeles, noted that the treatment is given intravenously, which “could be considered a significant drawback” compared to drugs taken by mouth.

It’s unclear how often patients would have to undergo the treatment.

Data and conclusions presented at meetings are typically considered preliminary until published in a peer-reviewed medical journal.

IHT-NYT News Syndicate
NEWS UPDATES
Oman
Oman University project panel reviews progress
Muna inaugurates Tawasul Centre for speech therapy
Meetings focus on improving defence ties with UK
Permanent Corner opens
Shinas hosts products expo
CSR summit focuses on boosting SMEs
Oman Air gets new country manager
Ithraa takes part in WEF special meet in Turkey
Other Top Stories
HK protesters defy Beijing, stay put
Al Qaeda attacks rebels in Yemen
Modi announces lifelong visas for PIOs
Nato’s Balkan expansion ‘a provocation’
Ghani sworn in as Afghanistan’s new president
India
Country looks for change, Modi tells CEOs in US
Chinese army incursions unacceptable, says Rijiju
Panneerselvam sworn in as TN CM; Jaya seeks bail
Jaitley moved to isolation ward
Government to launch health insurance scheme
Government officials told to join ‘Clean India’ campaign
PM vows to fulfil diaspora dreams
Modi’s words inspirational, visionary: Lawmakers
Modi, Israel PM pledge to promote ties
Prime minister shows sartorial elegance in US
Modi gets insight into US politics
Pakistan
Thousands of supporters attend PTI rally in Lahore
Rangers arrest 1,500 criminals in Karachi raid
Case filed against Sharif over killing of activists
Bilawal apologises to party workers for making mistakes
Five militants killed, four hurt in Tirah explosion
Floods turn boon for Sindh forests
Middle East
Libya rivals hold UN-brokered talks for reconciliation
Thousands throng Makkah for Haj
Rebel group members go on trial in Belgium over IS recruitment
US looks for ways to block IS fund flow
Asia
‘Umbrella Revolutionaries’ stay put
Dhaka arrests Briton over recruitment of IS militants
2 Chinese teens get death for murdering pro-Beijing imam
2 dead in decompression chamber at Japanese spa
Japan wary of possible Mt Fuji eruption
Business
Egypt plans $14.5b investments in oil, petrochem sectors
Dollar strengthens to 6-year high against yen
Doha Bank to acquire HSBC Oman’s India assets
CBO Board gives nod for appointing Sharia members
Pharma firms join global hunt for copycat drugs
Indian rupee dips to 7-month low against dollar
India scraps 9 SEZs over delay
GM begins vehicle exports from India plant
Strides Arcolab to buy Shasun Pharma
India textiles sector to get boost as exports seen rising 10% this year
Singareni to open biggest mine
Airlines fly slower to reduce fuel costs
Yahoo-AOL merger to boost growth
EU consumer confidence dips to 99.9 points in Sept.
‘No plans’ to ramp up Pimco
Europe
Osborne freezes welfare payments to balance books
Spain rolls out legal roadblock to stop Catalonia referendum
9 troops, 4 civilians killed in Ukraine despite truce
Blow to Hollande as right wins Senate, FN gets seats for first time
Karadzic kingpin of ‘Bosnia crimes’
Turkey suffers ‘rights rollback’ under Erdogan
Sports
Cagliari bring Inter coach to his knees
Valencia back in second spot with Sociedad draw
Afridi wants dignified exits for seniors
Marseille maintain winning momentum
Exiled Shakhtar dream of going home
PSG without Ibra for tie against Barcelona
Almouj clinch Chrysler Cup
Oman Sail’s new inititiave
‘Super Dan’ takes gold in epic Asian final
Sania-Saketh duo triumphs in tennis
‘Heads’ bring Kuwaiti cricketers win
Asians wary of African-born imports’ reign on tracks
Serena fights back to tame Soler-Espinosa
Americas
Republicans on track to win back Senate in mid-term vote
Fumbling agents get support of White House
Gunmen open fire at Miami club party, 15 injured
Mom of American who beheaded colleague apologises
58 students missing after Mexico protest crackdown
Canadian psycho admits to killing
More Americans now prefer to live alone

Sports


International

© 2013 Oman Tribune. All rights reserved. Best viewed in 800 X 600 resolution